This work examines how context may influence the detection of changes in flickering scenes. Each scene contained two changes that were matched for low-level visual salience. One of the changes was of high interest to the meaning of the scene, and the other was of lower interest. High-interest changes were more readily detected. To further examine the effects of contextual significance, we inverted the scene orientation to disrupt top-down effects of global context while controlling for contributions of visual salience. In other studies, inverting scene orientation has had inconsistent effects on detection of high-interest changes. However, this experiment demonstrated that inverting scene orientation significantly reduced the advantage for high-interest changes in comparison to lower-interest changes. Thus, scene context influences the deployment of attention and change-detection performance, and this top-down influence may be disrupted by scene inversion.