Atherothrombosis, inflammation, and diabetes

J Am Coll Cardiol. 2003 Apr 2;41(7):1071-7. doi: 10.1016/s0735-1097(03)00088-3.


Diabetes represents a major cause of cardiovascular morbidity and mortality in developed countries, and atherothrombosis accounts for most deaths among diabetics. Recent evidence has reliably shown the relevant etiopathogenetic role of inflammation in atherothrombotic disease. This review summarizes and discusses the possible synergistic effects of diabetes and inflammation in promoting atherothrombosis and its complications, as well as potential avenues for diagnostic, preventive, and therapeutic benefits in the modulation of inflammatory mechanisms in diabetic atherothrombotic disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / etiology*
  • Arteriosclerosis / physiopathology
  • Biomarkers
  • Clinical Trials as Topic
  • Diabetes Complications*
  • Diabetes Mellitus / physiopathology
  • Disease Progression
  • Humans
  • Inflammation / complications*
  • Inflammation / physiopathology
  • Risk Factors
  • Thrombosis / etiology*
  • Thrombosis / physiopathology
  • Transcription Factors / metabolism


  • Biomarkers
  • Transcription Factors