TCM-1: a nonlinear dynamical computational model to simulate cellular changes in the T cell system; conceptional design and validation

Anticancer Res. 2003 Jan-Feb;23(1A):123-35.

Abstract

Based upon a previously developed theory of dysregulative lymphoma pathogenesis, a computer model is designed in order to simulate cell changes occurring in disturbances of the T cell immune system and in lymphoproliferative diseases. The model is based upon the concept that factors identified as proliferation factors, differentiation factors and inhibition factors exert a network regulation upon development and function of the T cell system, and that selective disturbances of these factors may lead to hyperplastic, aplastic or neoplastic diseases. The resulting computer model (TCM-1) was validated by comparing it with data from human diseases such as acute HHV-6 (viral) infection, chronic persistent HHV-6 infection, progressive HIV1 infection and HTLV-1 infection, and comparing the simulation results with the actual cell data in the human patients. All these infections target the same T cell population (i.e. CD4 + T helper cells), yet cause different prototypical reactions (hyperplastic, aplastic, neoplastic). The described computer model, which was successfully used to simulate changes in the benign lymphoproliferative disease, Canale-Smith syndrome, will serve as the basis model for further supplementation to accommodate identified factorial influences such as by cytokines, chemokines and others.

MeSH terms

  • Adult
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / pathology
  • Cell Differentiation / immunology
  • Cell Division / immunology
  • Computer Simulation
  • HIV Infections / immunology
  • HIV-1
  • HTLV-I Infections / immunology
  • Herpesvirus 6, Human
  • Human T-lymphotropic virus 1
  • Humans
  • Lymphoproliferative Disorders / immunology*
  • Models, Immunological*
  • Nonlinear Dynamics
  • Roseolovirus Infections / immunology
  • T-Lymphocytes, Helper-Inducer / cytology
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / pathology
  • Virus Diseases / immunology*