Proteases and lung injury

Crit Care Med. 2003 Apr;31(4 Suppl):S189-94. doi: 10.1097/01.CCM.0000057842.90746.1E.

Abstract

Objective: Acute respiratory distress syndrome (ARDS) represents an inflammatory process that is initiated by diverse systemic and/or pulmonary insults, resulting in a clinical syndrome of severe respiratory distress and refractory hypoxemia. Neutrophils and their cytotoxic products, including oxidants and proteases, such as elastase, have been implicated as playing a key role in the pathophysiology of ARDS. This article reviews some of the physiologic actions of proteases, specifically elastase, the evidence for neutrophil elastase involvement in ARDS, and the potential therapeutic use of neutrophil elastase inhibitors in lung injury.

Data source: A review of published literature (original articles and reviews) in English from 1965 to 2002.

Conclusion: Although the data support a key role for neutrophil elastase in the pathogenesis of ARDS, further study is needed to fully define the actions of neutrophil elastase, and how these actions affect host functions, before we can exploit this knowledge for therapeutic benefit.

Publication types

  • Review

MeSH terms

  • Humans
  • Inflammation / complications
  • Leukocyte Elastase* / adverse effects
  • Leukocyte Elastase* / antagonists & inhibitors
  • Leukocyte Elastase* / physiology
  • Metalloendopeptidases / metabolism
  • Metalloendopeptidases / physiology
  • Respiratory Distress Syndrome, Adult* / enzymology
  • Respiratory Distress Syndrome, Adult* / etiology
  • Respiratory Distress Syndrome, Adult* / physiopathology

Substances

  • Leukocyte Elastase
  • Metalloendopeptidases