Effects of mobile phone radiation on reproduction and development in Drosophila melanogaster

J Cell Biochem. 2003 May 1;89(1):48-55. doi: 10.1002/jcb.10480.


In this report we examined the effects of a discontinuous radio frequency (RF) signal produced by a GSM multiband mobile phone (900/1,900 MHz; SAR approximately 1.4 W/kg) on Drosophila melanogaster, during the 10-day developmental period from egg laying through pupation. As found earlier with low frequency exposures, the non-thermal radiation from the GSM mobile phone increased numbers of offspring, elevated hsp70 levels, increased serum response element (SRE) DNA-binding and induced the phosphorylation of the nuclear transcription factor, ELK-1. The rapid induction of hsp70 within minutes, by a non-thermal stress, together with identified components of signal transduction pathways, provide sensitive and reliable biomarkers that could serve as the basis for realistic mobile phone safety guidelines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Phone* / standards
  • DNA-Binding Proteins*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / growth & development
  • Drosophila melanogaster / physiology
  • Drosophila melanogaster / radiation effects*
  • Female
  • Gene Expression Regulation / radiation effects
  • Genes, Insect / radiation effects
  • HSP70 Heat-Shock Proteins / metabolism
  • MAP Kinase Signaling System / radiation effects
  • Male
  • Ovulation / radiation effects
  • Proto-Oncogene Proteins / metabolism
  • Radio Waves / adverse effects*
  • Reproduction / radiation effects
  • Safety
  • Transcription Factors*
  • ets-Domain Protein Elk-1


  • DNA-Binding Proteins
  • Drosophila Proteins
  • HSP70 Heat-Shock Proteins
  • Proto-Oncogene Proteins
  • Transcription Factors
  • ets-Domain Protein Elk-1