[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone]

Eksp Klin Farmakol. 2003 Jan-Feb;66(1):20-2.
[Article in Russian]


A new drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats with global recurrent brain ischemia and in a model ischemic state under high radial gravitational overload. In the former case, the new drug increases the blood circulation in rats with the global ischemic damage to a greater extent than in the intact control group. Pretreatment with the pyroglutamic acid--pyrrolidone composition produced a 2-2.5-fold increase in the survival of rats in the ischemic state caused by the radial gravitational overload. The data obtained show evidence of a substantial neuroprotector action of the new drug composition.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Brain Ischemia / etiology
  • Brain Ischemia / physiopathology
  • Brain Ischemia / prevention & control*
  • Cerebrovascular Circulation / drug effects
  • Drug Combinations
  • Hypergravity / adverse effects
  • Ischemic Attack, Transient / physiopathology
  • Ischemic Attack, Transient / prevention & control
  • Neuroprotective Agents / administration & dosage*
  • Pyrrolidinones / administration & dosage*
  • Pyrrolidonecarboxylic Acid / administration & dosage*
  • Rats


  • Drug Combinations
  • Neuroprotective Agents
  • Pyrrolidinones
  • Pyrrolidonecarboxylic Acid