Signalling mechanisms in progesterone-neurotransmitter interactions

J Mol Endocrinol. 2003 Apr;30(2):127-37. doi: 10.1677/jme.0.0300127.


The current and expanded view of transcriptional regulation by the steroid/thyroid superfamily of nuclear transcription factors integrates not only the hormone-dependent but also the hormone-independent cellular signaling mechanisms in physiology and reproduction. This effort has vastly been aided by the identification of steroid hormone receptors as transcriptional mediators of a variety of ligands, whose transcriptional response is dependent upon cross-talk with distinct signal transduction pathways, their recruitment of coregulators, alteration of chromatin structure and identification of specific interactive motifs within the receptors themselves. This review will provide a framework for the current concepts in the field of steroid hormone action as exemplified by our studies on progesterone receptor in female sexual behavior.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Dopamine / chemistry
  • Dopamine / metabolism
  • Female
  • Gene Expression Regulation*
  • Neurotransmitter Agents / metabolism*
  • Progesterone / metabolism*
  • Receptors, Progesterone / chemistry
  • Receptors, Progesterone / genetics
  • Receptors, Progesterone / metabolism*
  • Sexual Behavior, Animal / physiology
  • Signal Transduction / physiology*


  • Neurotransmitter Agents
  • Receptors, Progesterone
  • Progesterone
  • Dopamine