Review
doi: 10.1016/s1570-9639(03)00077-3.
The multi-functional topa-quinone copper amine oxidases
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- PMID: 12686122
- DOI: 10.1016/s1570-9639(03)00077-3
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Review
The multi-functional topa-quinone copper amine oxidases
Biochim Biophys Acta.
.
Abstract
The mature copper amine oxidases (CAOs) contain a tyrosine-derived 2,4,5-trihydroxyphenylalanyl quinone (topa quinone or TPQ) and a cupric ion in close proximity. Through a combination of structural, spectroscopic and kinetic analyses, a chemical mechanism for the self-processing of an active site tyrosine to TPQ has been proposed. Once formed, TPQ acts as a switch between the heterolytic transformation of amine substrates to aldehydes, via a pyridoxal phosphate-like Schiff base complex, and one electron chemistry involving reduction of molecular oxygen. The relationship between the biogenetic and catalytic processes is discussed.
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