Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin

Leuk Lymphoma. 2003 Mar;44(3):525-9. doi: 10.1080/1042819021000035626.


In contrast to the majority of alphabeta peripheral T cell lymphomas (PTCL), which usually originate in lymph nodes and do not express NK-associated molecules, most gammadelta PTCL express a cytotoxic phenotype and originate at extranodal sites. We report a case of a patient with a gamma-delta PTCL who presented with large mandibular and parotidal lymphadenopathy and skin lesions. CD3(+)/TCR-Vdelta1 (+) lymphoma cells did not express the cell surface (CD11b, CD11c, CD16, CD56 and CD57) and cytoplasmic granule molecules (Perforin and Granzyme B) that usually characterize the cytotoxic T-cells, a phenotype that fulfils the criteria for diagnosis of a rare non-cytotoxic variant of a gammadelta T-cell lymphoma. "In situ" hybridization for Epstein-Barr virus-encoded RNA and latent membrane protein-1 gave negative results. The disease had an aggressive course and was resistant to chemotherapy and the patient died 4 months after diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Neoplasm / analysis
  • Biomarkers, Tumor / analysis
  • Diagnosis, Differential
  • Fatal Outcome
  • Female
  • Granzymes
  • Humans
  • Immunophenotyping
  • Lymph Nodes / chemistry
  • Lymph Nodes / pathology*
  • Lymphoma, T-Cell, Cutaneous / diagnosis
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Lymphoma, T-Cell, Peripheral / diagnosis
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Membrane Glycoproteins / analysis
  • Middle Aged
  • Neck
  • Neoplasm Proteins / analysis
  • Neoplastic Stem Cells / pathology
  • Perforin
  • Phenotype
  • Pore Forming Cytotoxic Proteins
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • Serine Endopeptidases / analysis
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / pathology*
  • T-Lymphocyte Subsets / pathology


  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Pore Forming Cytotoxic Proteins
  • Receptors, Antigen, T-Cell, gamma-delta
  • Perforin
  • GZMB protein, human
  • Granzymes
  • Serine Endopeptidases