DNA fuel for free-running nanomachines

Phys Rev Lett. 2003 Mar 21;90(11):118102. doi: 10.1103/PhysRevLett.90.118102. Epub 2003 Mar 18.


We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive free-running artificial molecular machines.

MeSH terms

  • Base Sequence
  • DNA / chemistry*
  • DNA / metabolism
  • Kinetics
  • Nanotechnology / methods*
  • Nucleic Acid Conformation
  • Nucleic Acid Hybridization*
  • Oligonucleotides / chemistry


  • Oligonucleotides
  • DNA