[Treatment of HIV-associated pulmonary hypertension with treprostinil]

Rev Esp Cardiol. 2003 Apr;56(4):421-5. doi: 10.1016/s0300-8932(03)76889-4.
[Article in Spanish]


Background and objective: The treatment of pulmonary hypertension associated with infection by human immunodeficiency virus has not been well defined. Treprostinil is a prostacyclin analogue that has recently been shown to be useful for the treatment of pulmonary hypertension, whether primary, secondary to congenital heart disease, or associated with collagen disease, in a 12-week, double-blind study. We report the results of a one-year follow-up of three patients with pulmonary hypertension associated with human immunodeficiency virus infection who are being treated with treprostinil at our center.

Patients and method: After secondary causes of pulmonary hypertension were excluded by a routine work-up, patients started treatment with subcutaneous prostacyclin (treprostinil) with progressive up-titration of the dose. Functional status and effort capacity were assessed every three months and an echocardiographic study was performed every six months.

Results: All patients showed improvement in clinical status, as shown by the NYHA functional class and the results of the six-minute walking test (increase of at least 75 meters). All the patients remain alive after one year of follow-up. Echocardiographic systolic pulmonary pressure decreased in two patients. No serious adverse events were observed.

Conclusions: Subcutaneous prostacyclin (treprostinil) seems to be an effective and safe therapeutic option for the treatment of pulmonary hypertension associated with human immunodeficiency virus infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antihypertensive Agents / therapeutic use*
  • Epoprostenol / analogs & derivatives
  • Epoprostenol / therapeutic use*
  • Female
  • HIV Infections / complications*
  • Hemodynamics / drug effects
  • Hemodynamics / physiology
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / etiology
  • Infusion Pumps
  • Infusions, Intravenous
  • Male
  • Treatment Outcome
  • Vasodilator Agents / therapeutic use


  • Antihypertensive Agents
  • Vasodilator Agents
  • Epoprostenol
  • treprostinil