Patterning systems--from one end of the limb to the other

Dev Cell. 2003 Apr;4(4):449-58. doi: 10.1016/s1534-5807(03)00095-9.

Abstract

A combination of embryology and gene identification has led us to the current view of vertebrate limb development, in which a series of three interlocking patterning systems operate sequentially over time. This review describes current understanding of these regulatory mechanisms and how they form a framework for future analysis of limb patterning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Patterning / genetics*
  • Extremities / embryology*
  • Fingers / embryology
  • Gene Expression Regulation, Developmental / genetics*
  • Growth Substances / genetics
  • Growth Substances / metabolism
  • Hedgehog Proteins
  • Humans
  • Mesoderm / metabolism
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Vertebrates / embryology*

Substances

  • Growth Substances
  • Hedgehog Proteins
  • Trans-Activators