The Nogo-66 receptor: focusing myelin inhibition of axon regeneration

Trends Neurosci. 2003 Apr;26(4):193-8. doi: 10.1016/S0166-2236(03)00062-6.


CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in signal transduction for several myelin-associated inhibitors. Additional studies have identified a potential coreceptor for NgR as p75(NTR), and a second-messenger pathway involving RhoA that inhibits neurite elongation. Although these findings expand our understanding of the molecular determinants of adult CNS axonal regrowth, the physiological roles of myelin-associated inhibitors in the intact adult CNS remain ill-defined.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / metabolism
  • Animals
  • Axons / physiology*
  • Cells, Cultured
  • GPI-Linked Proteins
  • Humans
  • In Vitro Techniques
  • Mice
  • Myelin Proteins / classification
  • Myelin Proteins / metabolism
  • Myelin Proteins / physiology*
  • Myelin Sheath / physiology*
  • Myelin-Associated Glycoprotein / metabolism
  • Myelin-Oligodendrocyte Glycoprotein
  • Nerve Regeneration / physiology*
  • Neural Inhibition / physiology*
  • Neuronal Plasticity
  • Nogo Proteins
  • Nogo Receptor 1
  • Rats
  • Receptor, Nerve Growth Factor
  • Receptors, Cell Surface / physiology*
  • Receptors, Nerve Growth Factor / metabolism
  • Signal Transduction / physiology


  • Acute-Phase Proteins
  • GPI-Linked Proteins
  • MOG protein, human
  • Mog protein, mouse
  • Mog protein, rat
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein
  • Nogo Proteins
  • Nogo Receptor 1
  • RTN4 protein, human
  • RTN4R protein, human
  • Receptor, Nerve Growth Factor
  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor
  • Rtn4 protein, mouse
  • Rtn4 protein, rat
  • Rtn4r protein, mouse
  • Rtn4r protein, rat
  • acute-phase protein rho