Variation at 16 STR loci in Rwandans (Hutu) and implications on profile frequency estimation in Bantu-speakers

Int J Legal Med. 2003 Apr;117(2):121-6. doi: 10.1007/s00414-002-0349-0. Epub 2003 Feb 15.

Abstract

A data set of 16 autosomal STRs (the 13 CODIS loci plus HumCD4, HumFES, HumF13A1) was obtained in a sample of 52 unrelated Hutus from Rwanda. Genotypes at all loci met Hardy-Weinberg expectations with the exception of HumCSF1PO. No significant evidence of association across alleles at independent loci was obtained. Statistical parameters demonstrated the forensic usefulness of the analysed systems (combined PE=0.9999996, combined PD=1:2.27 x 10(18)). Pairwise comparisons showed that the Hutu gene pool differs substantially from that of other Bantu-speaking populations suggesting the use of ethnic-specific population databases in forensic casework analysis. The introduction of a non-negligible bias was confirmed by calculating the differences between multiple-locus profile frequencies of western and eastern Bantoids using local and non-local reference databases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • African Continental Ancestry Group / genetics
  • Alleles
  • Databases, Genetic
  • Eyebrows / chemistry
  • Forensic Medicine
  • Gene Frequency / genetics*
  • Genetic Variation*
  • Genetics, Population
  • Genotype
  • Humans
  • Language
  • Rwanda
  • Tandem Repeat Sequences*