A randomized clinical trial of a wellness intervention for women with multiple sclerosis

Arch Phys Med Rehabil. 2003 Apr;84(4):467-76. doi: 10.1053/apmr.2003.50028.


Objective: To examine the effects of a wellness intervention program for women with multiple sclerosis (MS) on health behaviors and quality of life (QOL).

Design: Randomized clinical trial.

Setting: Community setting in the southwestern United States.

Participants: Convenience sample of 113 women with physician-confirmed MS (mean age, 45.79y).

Interventions: The 2-phase intervention program included lifestyle-change classes for 8 weeks, then telephone follow-up for 3 months. Participants were followed over an 8-month period.

Main outcome measures: A series of self-report instruments to measure barriers, resources, self-efficacy for health behaviors, health promotion behaviors, and health-related QOL were completed at baseline, 2 months (after the classes), 5 months (after telephone follow-up), and at 8 months. Principal outcomes measures were health-promoting behaviors (scores on the Health Promoting Lifestyle Profile II) and QOL (scores on the Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36] scales).

Results: Hierarchical linear modeling techniques revealed a statistically significant group by time effect for self-efficacy for health behaviors, health-promoting behaviors, and the mental health and pain scales of the SF-36.

Conclusion: These data provide initial support for the positive effects of wellness interventions to improve health behaviors and selected dimensions of QOL for women with MS.

Publication types

  • Clinical Trial
  • Comparative Study
  • Evaluation Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Chronic Disease
  • Data Collection / methods
  • Disabled Persons
  • Female
  • Health Behavior*
  • Health Promotion / methods*
  • Health Status Indicators
  • Humans
  • Life Style
  • Middle Aged
  • Multiple Sclerosis / rehabilitation*
  • Personal Satisfaction
  • Quality of Life
  • Treatment Outcome