The effect of arterial oxygen tension on antipyrine half-time in plasma

Clin Pharmacol Ther. 1976 Apr;19(4):498-71.


Hospital patients with depressed arterial oxygen tensions (PaO2) from pulmonary disease were given antipyrine orally or intravenously. The half-time (t1/2) of disappearance from plasma was measured. Other patients with normal PaO2 measurements were treated similarly. Patients whose PaO2 was 55 or below had longer t1/2 times than those of patients with a PaO2 above 55. This observation parallels that made previously in rats.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antipyrine / blood*
  • Half-Life
  • Humans
  • Lung Diseases / metabolism
  • Oxygen / blood*
  • Time Factors


  • Oxygen
  • Antipyrine