Neurobrucellosis in an endemic area of brucellosis

Scand J Infect Dis. 2003;35(2):94-7. doi: 10.1080/0036554021000027000.

Abstract

Central nervous system involvement occurs less than 5% of patients with brucellosis. A prospective analysis of 73 patients with brucellosis identified 13 (17.8%) neurobrucellosis cases from February 2001 to May 2002. 10 patients had chronic meningitis and 3 acute meningitis. Two patients had only psychiatric disorders. Cranial nerve involvement was observed in 3 patients (6th, 7th and 8th nerves). Three patients had positive blood cultures and 3 others had positive cerebrospinal fluid (CSF) cultures. 12 patients had positive agglutination titres in CSF. All patients received antibiotic therapy with ceftriaxone, rifampicin and doxycycline initially, and after 1 month they were continued with rifampicin and doxycycline up to 4 months. All patients were completely cured. Hearing loss developed in 1 patient as a sequela.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Anti-Bacterial Agents
  • Blood Chemical Analysis
  • Brucellosis / diagnosis*
  • Brucellosis / drug therapy
  • Brucellosis / epidemiology*
  • Cohort Studies
  • Drug Therapy, Combination / therapeutic use
  • Endemic Diseases / statistics & numerical data*
  • Female
  • Humans
  • Incidence
  • Male
  • Meningitis, Bacterial / diagnosis*
  • Meningitis, Bacterial / drug therapy
  • Meningitis, Bacterial / epidemiology*
  • Middle Aged
  • Neurologic Examination
  • Probability
  • Prognosis
  • Risk Factors
  • Sampling Studies
  • Severity of Illness Index
  • Sex Distribution
  • Spinal Puncture
  • Turkey / epidemiology

Substances

  • Anti-Bacterial Agents