CD4+CD25+ T cells as key regulators of immune responses

Eur J Dermatol. Mar-Apr 2003;13(2):111-6.


Discredited a few years ago, active suppression is now commonly considered as a key mechanism avoiding auto-reactivity and development of potentially harmful immune responses, and in some circumstances, as an obstacle to successful vaccination. A large quantity of literature identifies naturally occurring CD4+CD25+ T cells as key suppressor cells involved in the control of many pathophysiological diseases. Manipulation of these cells and control of their function offers new perspectives for the treatment of auto-immune and inflammatory diseases and enhancement of vaccine efficacy. Such clinical interventions require a better understanding of the conditions of expansion/activation of CD4+CD25+ T cells and deciphering of their mechanism of suppression, which remains incomplete and sometimes controversial.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Dermatitis, Contact / immunology
  • Humans
  • Immunity / immunology*
  • Lymphocyte Activation / immunology*
  • Receptors, Interleukin-2 / immunology*
  • T-Lymphocytes, Regulatory / immunology


  • Receptors, Interleukin-2