Abstract
We show that yeast protein Yel055cp, which has been identified as the fifth essential DNA polymerase in Saccharomyces cerevisiae (POL5), is a member of a family of predicted rDNA transcription regulators (typified by human MYB-binding protein MYBBP1 A), which are represented by a single ortholog in all animals, fungi and plants with sequenced genomes. These proteins are confidently predicted to have an entirely a-helical structure and are unrelated to the B class DNA polymerases, as claimed for yeast POL5, or any other known polymerases.
MeSH terms
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Amino Acid Sequence
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Animals
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Conserved Sequence
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DNA, Ribosomal / genetics
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DNA-Directed DNA Polymerase / classification*
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DNA-Directed DNA Polymerase / genetics*
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DNA-Directed DNA Polymerase / physiology
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Evolution, Molecular
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Gene Expression Regulation, Fungal
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Humans
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Molecular Sequence Data
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Saccharomyces cerevisiae / enzymology
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae Proteins / classification
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Saccharomyces cerevisiae Proteins / genetics*
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Saccharomyces cerevisiae Proteins / physiology
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Sequence Alignment
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Transcription, Genetic
Substances
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DNA, Ribosomal
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Saccharomyces cerevisiae Proteins
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DNA-Directed DNA Polymerase
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POL5 protein, S cerevisiae