Effects of air pollution on adults with chronic obstructive pulmonary disease

Arch Environ Health. Nov-Dec 2002;57(6):554-60. doi: 10.1080/00039890209602088.

Abstract

Few studies have been conducted on the effects of air pollution on patients with chronic obstructive pulmonary disease (COPD). During a 14-mo period, 39 Parisian adults with severe COPD were monitored by their physicians. Daily levels of 4 air pollutants were provided by an urban air-quality network. Exacerbation of COPD was associated only with ozone (O3) (odds ratio [OR] = 1.44 for a 10-microg/m3 increase in O3; 95% confidence interval [CI] = 1.14, 1.82), with a lag of 2-3 days. The effect of O3 was greater in patients whose carbon dioxide pressure (PaCO2) was higher than 43 mm Hg (OR = 1.83; 95% CI = 1.36, 2.47) vs. those with a lower PaCO2 (OR = 1.26; 95% CI = 0.90, 1.77). The effect of O3 was unchanged, regardless of the maintenance medications used. The only air pollutant to which patients with severe COPD were particularly sensitive was O3.

MeSH terms

  • Aged
  • Air Pollutants / analysis*
  • Air Pollution / analysis
  • Air Pollution / statistics & numerical data*
  • Carbon Monoxide / analysis
  • Disease Progression
  • Environmental Monitoring / statistics & numerical data*
  • Epidemiological Monitoring
  • Female
  • Follow-Up Studies
  • Humans
  • Humidity
  • Male
  • Middle Aged
  • Nitrogen Dioxide / analysis
  • Ozone / analysis
  • Pulmonary Disease, Chronic Obstructive / classification
  • Pulmonary Disease, Chronic Obstructive / epidemiology*
  • Seasons
  • Sulfur Dioxide / analysis
  • Temperature

Substances

  • Air Pollutants
  • Sulfur Dioxide
  • Ozone
  • Carbon Monoxide
  • Nitrogen Dioxide