Ibuprofen: alternative treatment for patent ductus arteriosus

Neonatal Netw. Mar-Apr 2003;22(2):27-31.


Patent ductus arteriosus (PDA) is a common problem for premature babies. Indomethacin, traditionally the treatment of choice for PDA closure, varies in effectiveness and can have serious side effects, such as intraventricular cerebral hemorrhage and decreased mesenteric and renal blood flow. Researchers abroad are examining the efficacy and safety of ibuprofen as an alternative PDA therapy. Their findings have been promising and indicate the need for clinical trials in the U.S.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Aorta / anatomy & histology
  • Aorta / pathology
  • Ductus Arteriosus, Patent / drug therapy*
  • Ductus Arteriosus, Patent / physiopathology
  • Humans
  • Ibuprofen / adverse effects
  • Ibuprofen / therapeutic use*
  • Indomethacin / therapeutic use
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / drug therapy*
  • Infant, Premature, Diseases / physiopathology
  • Respiratory Distress Syndrome, Newborn / drug therapy


  • Anti-Inflammatory Agents, Non-Steroidal
  • Ibuprofen
  • Indomethacin