Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules

Trends Immunol. 2003 Apr;24(4):155-8. doi: 10.1016/s1471-4906(03)00062-0.


Three members of the S100 family of calcium-binding proteins comprise a new group of proinflammatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.

Publication types

  • Review

MeSH terms

  • Calgranulin A / chemistry
  • Calgranulin A / metabolism
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Phagocytes / cytology
  • Phagocytes / immunology
  • Phagocytes / metabolism*
  • Protein Conformation
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / metabolism
  • S100 Proteins / genetics
  • S100 Proteins / immunology*
  • S100 Proteins / metabolism*
  • Signal Transduction


  • Calgranulin A
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic
  • S100 Proteins