Expression of CD94-NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells

Trends Immunol. 2003 Apr;24(4):162-4. doi: 10.1016/s1471-4906(03)00064-4.

Abstract

Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-cell receptor (TCR) engagement, commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine therapies.

MeSH terms

  • Animals
  • Antigens / immunology
  • Antigens, CD / immunology
  • Antigens, CD / metabolism*
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism*
  • Gene Expression Regulation
  • Humans
  • Lectins, C-Type / immunology
  • Lectins, C-Type / metabolism*
  • Lymphocyte Subsets / immunology
  • Lymphocyte Subsets / metabolism*
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / metabolism*
  • Receptors, Natural Killer Cell
  • Thymus Gland / cytology
  • Thymus Gland / immunology

Substances

  • Antigens
  • Antigens, CD
  • KLRC1 protein, human
  • KLRD1 protein, human
  • Lectins, C-Type
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D
  • Receptors, Immunologic
  • Receptors, Natural Killer Cell