Complicated left-sided native valve endocarditis in adults: risk classification for mortality

JAMA. 2003 Apr 16;289(15):1933-40. doi: 10.1001/jama.289.15.1933.


Context: Complicated left-sided native valve endocarditis causes significant morbidity and mortality in adults. Lack of valid data regarding estimation of prognosis makes management of this condition difficult.

Objective: To derive and externally validate a prognostic classification system for adults with complicated left-sided native valve endocarditis.

Design, setting, and patients: Retrospective observational cohort study conducted from January 1990 to January 2000 at 7 Connecticut hospitals among 513 patients older than 16 years who experienced complicated left-sided native valve endocarditis and who were divided into derivation (n = 259) and validation (n = 254) cohorts.

Main outcome measure: All-cause mortality at 6 months after baseline.

Results: In the derivation and validation cohorts, the 6-month mortality rates were 25% and 26%, respectively. Five baseline features were independently associated with 6-month mortality (comorbidity [P =.03], abnormal mental status [P =.02], moderate to severe congestive heart failure [P =.01], bacterial etiology other than viridans streptococci [P<.001 except Staphylococcus aureus, P =.004], and medical therapy without valve surgery [P =.002]) and were used to create a prognostic classification system. In the derivation cohort, patients were classified into 4 groups with increasing risk for 6-month mortality: 5%, 15%, 31%, and 59% (P<.001). In the validation cohort, a similar risk among the 4 groups was observed: 7%, 19%, 32%, and 69% (P<.001).

Conclusions: Adults with complicated left-sided native valve endocarditis can be accurately risk stratified using baseline features into 4 groups of prognostic severity. This prognostic classification system might be useful for facilitating management decisions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aortic Valve
  • Cohort Studies
  • Endocarditis / classification*
  • Endocarditis / mortality*
  • Endocarditis / surgery
  • Female
  • Heart Valve Diseases / classification*
  • Heart Valve Diseases / mortality*
  • Heart Valve Diseases / surgery
  • Humans
  • Male
  • Middle Aged
  • Mitral Valve
  • Prognosis
  • Reproducibility of Results
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Survival Analysis