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. 2003 Apr 22;88(8):1185-90.
doi: 10.1038/sj.bjc.6600895.

Construct Validation of the Health Utilities Index and the Child Health Questionnaire in Children Undergoing Cancer Chemotherapy

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Free PMC article

Construct Validation of the Health Utilities Index and the Child Health Questionnaire in Children Undergoing Cancer Chemotherapy

L Sung et al. Br J Cancer. .
Free PMC article

Abstract

The objective of this study was to evaluate the construct validity of two questionnaire-based measures of health-related quality of life (HRQL) in children undergoing cancer chemotherapy: the Health Utilities Index (HUI) and the Child Health Questionnaire (CHQ). Subjects were children hospitalised for chemotherapy. To examine construct validity: (1). a priori expected relations between CHQ concepts and HUI attributes were examined; (2). HUI and CHQ summary scores were compared to visual analogue scale (VAS) scores. Ease of completion was rated using a 5-point categorical scale and completion time was recorded. A total of 36 subjects were included. The maximum score was seen in 15 (47%) of HUI3 assessments. As predicted, CHQ body pain was moderately correlated with HUI3 pain (r=0.51), CHQ physical functioning was moderately correlated with HUI2 mobility (r=0.58) and CHQ mental health was moderately correlated with HUI2 emotion (r=0.53). Only the CHQ psychosocial subscale (and not HUI) was correlated with VAS (r=0.44). The CHQ and the HUI were both easy to use. The HUI questionnaires required less time to complete (mean=3.1, s.d.=1 min) compared with CHQ (mean=13.1, s.d.=3.4 min, P<0.0001). In conclusion, HUI and CHQ demonstrated construct validity in children undergoing cancer chemotherapy. The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete.

Figures

Figure 1
Figure 1
Scatterplot of HUI2 and VAS. The y-axis represents the scores on the HUI2 where 0 represents HRQL equal to death and 1 represents HRQL equal to perfect health. The x-axis represents the scores on the global HRQL VAS with the same anchors.
Figure 2
Figure 2
Scatterplot of CHQ PsS and VAS. The y-axis represents the scores on the CHQ PsS in which higher scores reflect better HRQL. The x-axis represents the scores on the global HRQL VAS in which 0 is equal to death and 1 is equal to perfect health. The line represents the least-squares regression line.
Figure 3
Figure 3
Bar graph illustrating the ease of completion of the different measures using a 5-point categorical scale. No-one rated any instrument as ‘difficult’ or ‘very difficult’ to complete.

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