Acute intermittent porphyria associated with ovarian stimulation. A case report

J Reprod Med. 2003 Mar;48(3):201-3.

Abstract

Background: Induction of ovulation in the course of infertility treatment is increasingly commonplace in the 21st century. As a consequence, it can be expected that previously unrecognized complications of the procedure will be reported.

Case: A 36-year-old woman presented with severe pelvic pain and hyponatremia after ovarian stimulation with gonadotropins. After admission with a presumptive diagnosis of ovarian hyperstimulation syndrome, a further family history revealed acute intermittent porphyria. A 24-hour urine collection confirmed the diagnosis.

Conclusion: Hormonal therapy for induction of ovulation in the course of infertility treatment may precipitate attacks of acute intermittent porphyria. A careful history must be undertaken prior to administration of such hormonal preparations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Follicle Stimulating Hormone / adverse effects*
  • Hormones / adverse effects*
  • Humans
  • Ovulation Induction / adverse effects*
  • Porphyria, Acute Intermittent / chemically induced*
  • Porphyria, Acute Intermittent / diagnosis
  • Porphyria, Acute Intermittent / therapy
  • Pregnancy

Substances

  • Hormones
  • Follicle Stimulating Hormone