An investigation on the influence of different types of oral contraceptives upon serum gonadotropins, estradiol and progesterone was carried out in 10 volunteers. The effect of a change from a normophasic type preparation to a sequential preparation (Ovanon and Kombiquens) and from a combined preparation to a minipill (Neogynon and Exlutona) was studied. Two new 3-phase step-up preparations were also tested. Ovulation was inhibited in each case as the preovulatory LH-peak and the subsequent rise of serum progesterone were found to be missing. The basal LH- and FSH-secretion and serum estradiol were demonstrated to be significantly diminished in the volunteers taking combined and sequential preparations. The release of gonadotropines was not inhibited as much when the 3-phase step-up preparations (SHB 261 AB and SHB 264 AB) were used. When Exlutona was taken, the basal LH-secretion was lower than during the pre- and postovulatory phase of the normal cycle, but follicular development did not appear to be inhibited much as both FSH and estradiol were found to be in the normal range.
PIP: 10 women, 91-32 years old, were studied concerning the influence of different types of oral contraceptives upon serum gonadotropins, estradiol, and progesterone; 7 women with normal ovulation served as a control group. Observations were made of changes from a normophasic type preparation to a sequential preparation (Ovanon and Kambiquens) and from a combination pill to a minipill (Neogynon and Exlutona). 2 new 3-phased preparations (SHB 261 AB and SHB 264 AB) were also tested. Ovulation was inhibited in each case as the prevoulatory luteinizing hormone (LH) peak and subsequent rise of serum progesterone were found to be missing. Basal LH and follicle stimulating hormone (FSH) secretion and serum estradiol were demonstrated to be significantly diminished in the volunteers taking combined and sequential preparations. 3-phase preparations inhibited the relase of gonadotropins to a greater extent. When Exlutona was taken, basal LH secretion was lower than during the pre- and postovulatory phase of the normal cycle, but follicular development did not seem to be inhibited much, as both FSH and estradiol were in the normal range.