Peripheral and central activation of trigeminal pain pathways in migraine: data from experimental animal models

Cephalalgia. 2003:23 Suppl 1:1-4. doi: 10.1046/j.1468-2982.23.s1.1.x.


Animal models for migraine have provided substantial advances on the mechanisms and mediators underlying migraine attacks. The neurogenic inflammation model has helped understanding the perivascular mechanisms underlying the pathophysiology of migraine attacks, the receptors involved and the effect of specific antimigraine drugs. The model based on probing the neuronal effects of nitroglycerin--an organic nitrate known to induce spontaneous-like migraine attacks in predisposed subjects--in the rat has provided interesting insights into the neuroanatomic circuits and neuropharmacological mechanisms involved in the initiation and repetition of migraine attacks [corrected].

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / blood supply
  • Brain / drug effects
  • Migraine Disorders / chemically induced
  • Migraine Disorders / drug therapy
  • Migraine Disorders / physiopathology*
  • Models, Animal
  • Neurogenic Inflammation / physiopathology*
  • Nitric Oxide / metabolism
  • Nitric Oxide Donors / pharmacology
  • Nitroglycerin / pharmacology
  • Pain / physiopathology*
  • Trigeminal Nerve / physiopathology


  • Nitric Oxide Donors
  • Nitric Oxide
  • Nitroglycerin