Abstract
To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.
MeSH terms
-
Animals
-
Area Under Curve
-
Carotid Arteries
-
Collateral Circulation / drug effects*
-
Cysteine / analogs & derivatives
-
Cysteine / chemical synthesis
-
Cysteine / pharmacology
-
Dogs
-
Drug Tolerance
-
Injections, Intravenous
-
Male
-
Nitrates / chemical synthesis*
-
Nitrates / pharmacology
-
Nitric Oxide Donors / chemical synthesis*
-
Nitric Oxide Donors / pharmacology
-
Nitroglycerin / pharmacology
-
Sulfhydryl Compounds / chemistry*
-
Thiazoles / chemical synthesis*
-
Thiazoles / pharmacology
-
Vasodilator Agents / adverse effects
-
Vasodilator Agents / chemical synthesis
-
Vasodilator Agents / pharmacology*
Substances
-
Nitrates
-
Nitric Oxide Donors
-
Sulfhydryl Compounds
-
Thiazoles
-
Vasodilator Agents
-
Nitroglycerin
-
Cysteine