Cell division

Nature. 2003 Apr 17;422(6933):746-52. doi: 10.1038/nature01599.


In creating the mitotic spindle and the contractile ring, natural selection has engineered fascinating precision machines whose movements depend upon forces generated by ensembles of cytoskeletal proteins. These machines segregate chromosomes and divide the cell with high fidelity. Current research on the mechanisms and regulation of spindle morphogenesis, chromosome motility and cytokinesis emphasizes how ensembles of dynamic cytoskeletal polymers and multiple motors cooperate to generate the forces that guide the cell through mitosis and cytokinesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Chromosome Segregation*
  • Cytoskeleton / metabolism*
  • Mitosis*
  • Models, Biological
  • Molecular Motor Proteins / metabolism*
  • Spindle Apparatus / metabolism*


  • Molecular Motor Proteins