Resistin: molecular history and prognosis

J Mol Med (Berl). 2003 Apr;81(4):218-26. doi: 10.1007/s00109-003-0428-9. Epub 2003 Mar 28.


Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Regulation
  • Glucocorticoids / metabolism
  • Glucose / metabolism
  • Hormones, Ectopic / genetics*
  • Hormones, Ectopic / physiology*
  • Hypoglycemic Agents / therapeutic use
  • Insulin / metabolism
  • Intercellular Signaling Peptides and Proteins*
  • Ligands
  • Mice
  • Molecular Sequence Data
  • NIH 3T3 Cells
  • Nerve Growth Factor
  • Obesity / genetics
  • Protein Structure, Tertiary
  • Proteins*
  • Resistin
  • Sequence Homology, Amino Acid
  • Thiazolidinediones / therapeutic use


  • Glucocorticoids
  • Hormones, Ectopic
  • Hypoglycemic Agents
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Proteins
  • RETNLB protein, human
  • Resistin
  • Retn protein, mouse
  • Retnla protein, mouse
  • Thiazolidinediones
  • Nerve Growth Factor
  • 2,4-thiazolidinedione
  • Glucose