Toward a realistic model of mutations affecting fitness

Evolution. 2003 Mar;57(3):683-5; discussion 686-9. doi: 10.1111/j.0014-3820.2003.tb01561.x.


Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

Publication types

  • Comment

MeSH terms

  • Animals
  • Arabidopsis / genetics*
  • Arabidopsis / physiology
  • Biological Evolution
  • Models, Genetic
  • Mutation*
  • Phenotype
  • Reproduction
  • Selection, Genetic*