Leucine 2,3-aminomutase, an enzyme of leucine catabolism

J Biol Chem. 1976 Apr 10;251(7):1859-63.


The initial step in the fermentation of leucine to acetate, isobutyrate, and ammonia by Clostridium sporogenes is the B12 coenzyme-dependent conversion of alpha-leucine to beta-leucine (3-amino-4-methylpentanoate). The amino group migration reaction, catalyzed by leucine 2,3-aminomutase, is reversible and is inhibited by intrinsic factor. The enzyme activity has been found in several clostridia, in rat, sheep, rhesus, and African green monkey livers, and in human leukocytes.

MeSH terms

  • Amino Acid Isomerases / metabolism*
  • Animals
  • Bacterial Proteins / physiology
  • Clostridium / enzymology*
  • Intramolecular Transferases
  • Kidney / enzymology
  • Kinetics
  • Leucine / metabolism*
  • Liver / enzymology
  • Species Specificity
  • Spores, Bacterial / enzymology


  • Bacterial Proteins
  • Amino Acid Isomerases
  • Intramolecular Transferases
  • leucine 2,3-aminomutase
  • Leucine