The Audio Computer Assisted Self-Interview (ACASI) is a computer application that allows a research participant to hear survey interview items over a computer headset and read the corresponding items on a computer monitor. The ACASI automates progression from one item to the next, skipping irrelevant items. The research participant responds by pressing a number keypad, sending the data directly into a database. The ACASI was used to enhance participants' sense of privacy. A convenience sample of 257 young urban women, ages 18 to 29 years, were interviewed in neighborhood settings concerning human immune deficiency virus (HIV) sexual risk behaviors. Notebook computers were used to facilitate mobility. The overwhelming majority rated their experience with ACASI as easy to use. This article will focus on the use of ACASI in HIV behavioral research, its benefits, and approaches to resolve some identified problems with this method of data collection.