Advances in the biology of JC virus and induction of progressive multifocal leukoencephalopathy

J Neurovirol. 2003 Apr;9(2):236-46. doi: 10.1080/13550280390194019.


Since the initial description of progressive multifocal leukoencephalopathy (PML) in 1958, clinical and basic science investigators have demonstrated a growing interest in the area of neurovirology, with a recent focus on polyomaviruses. In this review, the authors present an overview of the biological properties of the human polyomavirus, JC virus (JCV), and its association with PML as the etiologic agent. Additionally, the authors provide a discussion of the current understanding of JCV molecular pathogenesis and therapeutic strategies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Humans
  • Incidence
  • JC Virus / physiology*
  • Leukoencephalopathy, Progressive Multifocal / drug therapy*
  • Leukoencephalopathy, Progressive Multifocal / epidemiology
  • Leukoencephalopathy, Progressive Multifocal / virology*


  • Antiviral Agents