Lambert-Eaton Myasthenic syndrome in a child with an autoimmune phenotype

Am J Med Genet A. 2003 May 15;119A(1):77-80. doi: 10.1002/ajmg.a.20022.


We report on a child with a family history of autoimmune defects, who presented at the age of 3(1/2) years with alopecia and Graves disease. He subsequently developed vitiligo and psoriasis. At 9(1/2) years, he developed an autoimmune form of Lambert-Eaton Myasthenic syndrome (LEMS) with a significant elevation of glutamic acid decarboxylase (GAD) autoantibodies. Shortly thereafter he developed chronic urticaria. HLA associations were present for Graves disease, vitiligo, psoriasis, and IgA deficiency. There was also evidence of autoimmunity involving the pancreatic islet cells and gastric parietal cells.

Publication types

  • Case Reports

MeSH terms

  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Child
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics
  • Humans
  • Lambert-Eaton Myasthenic Syndrome / genetics
  • Lambert-Eaton Myasthenic Syndrome / immunology*
  • Male


  • HLA Antigens