The effect of propofol (anesthetic and inhibitor of CYP3A4) on serum lidocaine concentrations in smokers and chronic alcohol consumers

Int J Clin Pharmacol Ther. 2003 Apr;41(4):182-4. doi: 10.5414/cpp41182.
No abstract available

Publication types

  • Clinical Trial
  • Comparative Study
  • Letter

MeSH terms

  • Adult
  • Aged
  • Alcoholism / metabolism*
  • Anesthetics / blood
  • Anesthetics / pharmacology*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • Humans
  • Injections, Intravenous
  • Lidocaine / blood*
  • Middle Aged
  • Propofol / pharmacology*
  • Smoking / metabolism*

Substances

  • Anesthetics
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System
  • Lidocaine
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Propofol