The structure and function of proline recognition domains

Sci STKE. 2003 Apr 22;2003(179):RE8. doi: 10.1126/stke.2003.179.re8.


One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a critical role in the assembly and regulation of many intracellular signaling complexes. These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Proline / chemistry*
  • Proline / physiology*
  • Protein Structure, Tertiary / physiology
  • Structure-Activity Relationship
  • src Homology Domains / physiology


  • Proline