Lack of association between B19 or V9 erythrovirus infection and ANCA-positive vasculitides: a case-control study

Rheumatology (Oxford). 2003 May;42(5):660-4. doi: 10.1093/rheumatology/keg206.


Objectives: To examine the potential association of human B19 or V9 erythrovirus infection and onset of ANCA-positive vasculitides.

Methods: We tested the sera of 13 adults with newly diagnosed ANCA-positive vasculitides. Each was age- and sex-matched to three sera obtained from healthy controls. All samples were tested for B19- and V9-specific immunoglobulin (Ig) G and IgM antibodies (Ab) (third-generation ELISA), and B19 or V9 DNA was sought with the polymerase chain reaction. Statistical analysis was performed by conditional logistic regression.

Results: Patient diagnoses comprised six cases of Wegener's granulomatosis, six of microscopic polyangiitis and one of Churg-Strauss syndrome. IgG Ab to B19 were detected equally in patient and control sera (77 and 79% respectively) (odds ratio=0.84, P=0.84). All 13 cases and 39 controls were negative for IgM Ab and viral DNA.

Conclusion: These results suggest that neither acute nor chronic B19 or V9 infection is an aetiological factor in ANCA-associated vasculitides.

MeSH terms

  • Acute Disease
  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / blood*
  • Antibodies, Viral / blood
  • Case-Control Studies
  • Chronic Disease
  • Churg-Strauss Syndrome / virology
  • DNA, Viral / blood
  • Erythrovirus / immunology
  • Erythrovirus / isolation & purification*
  • Female
  • Granulomatosis with Polyangiitis / virology
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Logistic Models
  • Male
  • Middle Aged
  • Parvoviridae Infections / complications*
  • Parvovirus B19, Human / immunology
  • Parvovirus B19, Human / isolation & purification
  • Vasculitis / virology*


  • Antibodies, Antineutrophil Cytoplasmic
  • Antibodies, Viral
  • DNA, Viral
  • Immunoglobulin G
  • Immunoglobulin M