Recurrent plunging ranula treated with OK-432

Eur Arch Otorhinolaryngol. 2003 Apr;260(4):226-8. doi: 10.1007/s00405-002-0482-x. Epub 2002 Nov 8.


A 36-year-old man was admitted who had a 2-month history of swelling of the right submandibular area and the right side of the mouth floor. He had undergone operations for right plunging ranula with a lesion on the floor of the mouth twice 7 years ago. Under fluoroscopic guidance, the contents of the cyst were aspirated as much as possible and injected with the same amount of OK-432 solution (Picibanil 0.1 mg; 10 ml) twice with 3-week intervals. Examination after 6 weeks showed that the cystic mass seen before therapy had disappeared completely, and no recurrence was encountered after 1 year. We here report a case in which a successful sclerotherapy with OK-432 for recurrent plunging ranula after surgery was performed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use*
  • Humans
  • Male
  • Picibanil / therapeutic use*
  • Ranula / therapy*
  • Recurrence
  • Sclerosing Solutions / therapeutic use*
  • Sclerotherapy / methods


  • Antineoplastic Agents
  • Sclerosing Solutions
  • Picibanil