Biomarker assays for phosphorylated MAP kinase. Their utility for measurement of MEK inhibition

Methods Mol Med. 2003;85:31-8. doi: 10.1385/1-59259-380-1:31.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Biomarkers / analysis*
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Jurkat Cells / drug effects
  • Jurkat Cells / enzymology
  • Lymphocyte Activation / drug effects
  • MAP Kinase Kinase 1
  • MAP Kinase Signaling System / drug effects
  • Mice
  • Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors*
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Mitogen-Activated Protein Kinases / metabolism*
  • Neoplasm Proteins / antagonists & inhibitors
  • Neoplasm Proteins / metabolism
  • Phosphoproteins / metabolism*
  • Phosphorylation / drug effects
  • Protein Processing, Post-Translational / drug effects*
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / metabolism
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Antineoplastic Agents
  • Biomarkers
  • Enzyme Inhibitors
  • Neoplasm Proteins
  • Phosphoproteins
  • Protein-Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 1
  • MAP2K1 protein, human
  • Map2k1 protein, mouse
  • Mitogen-Activated Protein Kinase Kinases
  • Tetradecanoylphorbol Acetate