Reversibility of the effects on blood cells, lipids, liver function and hormones in former anabolic-androgenic steroid abusers

J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):369-75. doi: 10.1016/s0960-0760(03)00105-5.


Background: In contrast to the acute effects of anabolic-androgenic steroid (AAS) abuse, the long-term risk profile of former long-term abusers (ExA) is less clear.

Methods: Blood parameters of 32 male bodybuilders and powerlifters were studied. Fifteen ExA had not been abusing AAS for at least 12-43 months on average (mean dosage 700 mg for 26 weeks per year over 9 years), 17 athletes (A) were still abusing AAS (750 mg for 33 weeks per 8 years).

Findings: Hemoglobin (+5%), leucocytes (+33%) and platelets (+38%) were significantly higher in A. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were higher, cholinesterase activity (CHE) lower in A (65+/-55, 38+/-27 and 3719+/-1528U/l) compared to ExA (24+/-10, 18+/-11 and 6345+/-975U/l; each P<0.001) with normal values for gamma-glutamyl transpeptidase (gamma-GT) and bilirubin. ALT, AST and CHE correlated significantly with the extent (duration and weekly dosage, expressed as a point score) of AAS abuse in A (r=0.68, 0.57 and -0.62; each P<0.01). Total and LDL-cholesterol were similar, HDL-cholesterol was distinctly lower in A than in ExA (17+/-11 and 43+/-11 mg/dl; P<0.001) and correlated negatively with the extent of AAS abuse (r=-0.50; P<0.05). Testosterone and estradiol were significantly higher, while LH, FSH and the sexual-hormone-binding (SHB) protein were lower in A than in ExA (each P<0.001). Two ExA had testosterone levels below the normal range.

Interpretation: The alterations in cell counts, HDL-cholesterol, liver function and most hormones of the pituitary-testicular axis induced by a long-term abuse of AAS were reversible after stopping the medication for over 1 year. In some ExA, an increased ALT activity and a depressed testosterone synthesis were found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anabolic Agents / adverse effects*
  • Blood Cells / drug effects*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Creatine Kinase / metabolism
  • Doping in Sports
  • Estradiol / blood
  • Hormones / blood
  • Humans
  • Lipid Metabolism*
  • Liver / diagnostic imaging
  • Liver / drug effects*
  • Male
  • Testosterone / blood
  • Time Factors
  • Ultrasonography


  • Anabolic Agents
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Hormones
  • Testosterone
  • Estradiol
  • Creatine Kinase