Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus

Ian van Altena; Rob van Soest; Michel Roberge; Raymond J Andersen

doi:10.1021/np0205147

Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus

J Nat Prod. 2003 Apr;66(4):561-3. doi: 10.1021/np0205147.

Authors

Ian van Altena¹, Rob van Soest, Michel Roberge, Raymond J Andersen

Affiliation

¹ Department of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.

PMID: 12713417
DOI: 10.1021/np0205147

Abstract

The structure of trisphaerolide A (1), a mildly cytotoxic metabolite isolated from extracts of the marine sponge Erylus trisphaerus collected in Dominica, has been elucidated by detailed analysis of spectroscopic data. Trisphaerolide A (1) has a putative polyketide biogenesis, incorporating a rare variant on the standard pathway, which involves the addition of methyl branches arising from C-2 carbons of acetate units to chain carbons that arise from C-1 of acetate units.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Benzene Derivatives / chemistry
Benzene Derivatives / isolation & purification*
Benzene Derivatives / pharmacology
Dominica
Drug Screening Assays, Antitumor
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Benzene Derivatives
Lactones
trisphaerolide A