Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review

Pathol Int. 2003 May;53(5):297-302. doi: 10.1046/j.1440-1827.2003.01470.x.


Clear cell ependymoma has been included in the WHO classification of the central nervous system in 1993, after the first report by Kawano et al. Since then, only a few cases have been reported. Most clear cell ependymoma cases reported in the literature so far were located in the supra-tentorial compartment and/or cerebellum, and one case was in the cervical spinal cord. We report a case of clear cell ependymoma whose histological features were sufficient for the diagnosis and was unusually located in the fourth ventricle originating from the medulla oblongata. The tumor showed uniform tumor cells with perinuclear halo, nuclei being centrally located. Most of the tumor cells were arranged as perivascular pseudorosettes, and no ependymal canals or rosettes were evident. Mitotic figures were not frequent. Immunohistochemically, the tumor cells were strongly reactive for glial fibrillary acidic protein and vimentin, and weak and dot-like positive for epithelial membrane antigen. Clear cell change of the tumor cells appeared to be fixation artifact because this feature was not evident in the frozen section.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biomarkers, Tumor
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery
  • Ependymoma / pathology*
  • Ependymoma / surgery
  • Humans
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Male
  • Medulla Oblongata / pathology*
  • Medulla Oblongata / surgery
  • Neoplasm Proteins / analysis
  • Treatment Outcome


  • Biomarkers, Tumor
  • Neoplasm Proteins