Bleeding, salicylates, and prolonged prothrombin time: three case reports and a review of the literature

J Rheumatol. 1976 Mar;3(1):37-42.


Fourteen cases of ASA induced hypoprothrombinemic bleeding, including three patients reported by the authors, are reviewed. Predisposing factors toward bleeding include malnutrition and malabsorption syndrome. Although the bleeding is usually benign, it may be serious on occasion. The importance of this rarely considered cause of ASA associated bleeding lies in the fact that it is readily corrected with Vitamin K.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / drug therapy*
  • Aspirin / adverse effects*
  • Aspirin / therapeutic use
  • Epistaxis / chemically induced
  • Female
  • Humans
  • Hypoprothrombinemias / chemically induced*
  • Hypoprothrombinemias / drug therapy
  • Malabsorption Syndromes / complications
  • Male
  • Middle Aged
  • Nutrition Disorders / complications
  • Vitamin K / therapeutic use


  • Vitamin K
  • Aspirin