Regulation of mRNA translation by 5'- and 3'-UTR-binding factors

Trends Biochem Sci. 2003 Apr;28(4):182-8. doi: 10.1016/S0968-0004(03)00051-3.


The translational regulation of specific mRNAs is important for controlling gene expression. The past few years have seen a rapid expansion in the identification and characterization of mRNA regulatory elements and their binding proteins. For the majority of these examples, the mechanism by which translational regulation is achieved is not well understood. Nevertheless, detailed analyses of a few examples show that almost every event in the initiation pathway, from binding of the cap complex to the joining of the 60S ribosomal subunit, is subject to regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3' Untranslated Regions*
  • 5' Untranslated Regions*
  • Animals
  • Arachidonate 15-Lipoxygenase / genetics
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Gene Expression Regulation*
  • Humans
  • Iron-Regulatory Proteins / metabolism
  • Protein Biosynthesis*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / metabolism*


  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • Drosophila Proteins
  • Iron-Regulatory Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • osk protein, Drosophila
  • Arachidonate 15-Lipoxygenase