[Distal myasthenia gravis: case report]

Arq Neuropsiquiatr. 2003 Mar;61(1):119-20. doi: 10.1590/s0004-282x2003000100024. Epub 2003 Apr 16.
[Article in Portuguese]


We report the case of a 30-year-old woman with a 7-year history of distal lower limbs weakness that evolved to upper limbs weakness. On neurological examination, she presented normal cranial nerves, bilateral quadriceps and feet interosseous atrophy, normal muscular tonus, muscular weakness more severe in dorsal feet interosseous and anterior tibial, and decreased deep tendon reflexes. Repetitive nerve stimulation of the ulnar and fibular nerves showed a decrement greater than 10% of the compound muscle action potential. Antibody against acetylcholine receptor titer was positive. Computed tomography scan of the thorax was normal. Thyroid function tests showed evidence of hyperthyroidism. Distal muscular weakness is a rare onset presentation of myasthenia gravis. However, myasthenia gravis must be considered in the differential diagnosis of distal limb weakness.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Electric Stimulation / methods
  • Female
  • Humans
  • Leg
  • Muscle Contraction
  • Muscle Weakness / diagnosis
  • Muscle Weakness / etiology*
  • Myasthenia Gravis / complications*
  • Myasthenia Gravis / diagnosis