[Nicergoline in the treatment of patients after a mild ischemic stroke]

Neurol Neurochir Pol. 2002 Nov-Dec;36(6):1075-85.
[Article in Polish]


25 patients with neurological and neuropsychological deficits after a mild ischaemic stroke were treated with nicergoline (Adavin 60 mg/d) versus placebo in a double blind cross-over trial (3 and 3 months). The patients were examined repeatedly by a neurologist and a neuropsychologist using a battery of tests (PPL, AVLT, Benton and Bourdon tests, number-repetition test). On completion of the trial the improvement of neurological signs (mainly cerebellar deficits) and neuropsychological impairments (in particular of attention and manual manipulation difficulties) was found to be more marked after the period of nicergoline treatment than after placebo. No drug-dependent side effects--including the influence on blood pressure--were observed in the whole group treated.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / etiology
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology
  • Electrocardiography
  • Female
  • Humans
  • Hypertension / complications
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Nicergoline / administration & dosage
  • Nicergoline / therapeutic use*
  • Severity of Illness Index
  • Time Factors
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use*


  • Vasodilator Agents
  • Nicergoline