Raised nitrate concentration and low SOD activity in the CSF of sporadic ALS patients

Neurochem Res. 2003 May;28(5):699-703. doi: 10.1023/a:1022853531855.

Abstract

To determine whether or not the occurrence of sporadic amyotrophic lateral sclerosis (sALS) is associated with both excess nitric oxide (NO) metabolites and decreased protective superoxide dismutase (SOD) activity in the cerebrospinal fluid (CSF), we measured nitrate concentration and SOD activity in the CSF of sALS patients and in age- and gender-matched controls. We found stable NO metabolite levels to be significantly higher and SOD activity lower in the CSF of sALS patients. In addition, SOD showed a negative correlation with motor neuron axonal damage expressed as the amplitude of motor action potentials in upper limbs. Our results provide new evidence in vivo suggesting that NO products and SOD activity play a role in oxidant/ antioxidant imbalance in sporadic ALS.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Disease Progression
  • Evoked Potentials / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Neuron Disease / cerebrospinal fluid*
  • Motor Neuron Disease / enzymology
  • Motor Neuron Disease / physiopathology
  • Nitrates / cerebrospinal fluid*
  • Nitric Oxide / cerebrospinal fluid*
  • Reference Values
  • Regression Analysis
  • Risk Factors
  • Superoxide Dismutase / cerebrospinal fluid*
  • Ulnar Nerve / physiopathology

Substances

  • Nitrates
  • Nitric Oxide
  • Superoxide Dismutase