Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene

Genesis. 2003 Apr;35(4):227-38. doi: 10.1002/gene.10188.


By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Crosses, Genetic
  • Integrases / genetics
  • Integrases / metabolism
  • Mice
  • Mice, Transgenic
  • Muscle, Skeletal / metabolism*
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism


  • Transforming Growth Factor beta
  • Viral Proteins
  • Cre recombinase
  • Integrases